Research in the field of self-regulated learning (SRL) reveals that many learners have trouble managing and regulating their learning activities with e-learning systems. One vital factor in successful e-learning activities is learners’ SRL abilities. Many studies have developed e-learning design principles that can encourage and support learners to self-regulate their e-learning, specifically actively processing e-learning contents and materials. These design principles are based upon the framework of SRL, which represents important concepts as phases and components. This entry first explains the concepts of SRL and research on SRL in e-learning environments. It then discusses e-learning design principles to promote students’ SRL abilities.