Maternal Deprivation

Maternal deprivation (MD) is an animal model of early-life stress, in which the animals are separated from their mother early in the postnatal period, thereby causing a strong stress that causes remarkable long-lasting consequences in the individuals. Several animal models of early-life stress have been developed, and a wide variety are based on the disruption of the “natural” maternal-pup interaction during early postnatal life. In rats, the MD animal model consists in a prolonged single episode (24 hours) of separation of the whole litter from the dam on Postnatal Day 9. MD has been reported to induce short- and long-term neurobiological and behavioral effects. Although MD was initially proposed as a valid animal model to investigate schizophrenia, it was also extensively employed to investigate the ...

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