• Entry
  • Reader's guide
  • Entries A-Z
  • Subject index

Maternal Deprivation

Maternal deprivation (MD) is an animal model of early-life stress, in which the animals are separated from their mother early in the postnatal period, thereby causing a strong stress that causes remarkable long-lasting consequences in the individuals. Several animal models of early-life stress have been developed, and a wide variety are based on the disruption of the “natural” maternal-pup interaction during early postnatal life. In rats, the MD animal model consists in a prolonged single episode (24 hours) of separation of the whole litter from the dam on Postnatal Day 9. MD has been reported to induce short- and long-term neurobiological and behavioral effects. Although MD was initially proposed as a valid animal model to investigate schizophrenia, it was also extensively employed to investigate the ...

    • Loading...
    locked icon

    Sign in to access this content

    Get a 30 day FREE TRIAL

    • Watch videos from a variety of sources bringing classroom topics to life
    • Read modern, diverse business cases
    • Explore hundreds of books and reference titles