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Major or Mild Neurocognitive Disorder With Lewy Bodies

Major or mild neurocognitive disorder with Lewy bodies, also commonly termed dementia with Lewy bodies (DLB), is a syndrome in which patients develop cognitive decline in combination with a Parkinson-like motor syndrome. It is recognized as a distinct clinical condition characterized by the presence of visual hallucinations and cognitive fluctuations along with cognitive decline and a Parkinsonian movement disorder. As discussed in this entry, there is a significant amount of clinical and pathological overlap with other dementias such as Alzheimer’s disease (AD) and Parkinson’s disease dementia (PDD), and as a result, the relation among these disorders remains controversial.

Epidemiology

DLB is the second most common form of neurodegenerative dementia after AD and accounts for between 15% and 20% of all dementias. The estimated population prevalence is between ...

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