Major or Mild Neurocognitive Disorder due to Parkinson’s Disease

Parkinson’s disease (PD) is one of the many subcortical neurodegenerative diseases (i.e., degenerative diseases that primarily affect the subcortical regions of the brain), and many patients with this disease will develop dementia (PDD—Parkinson’s disease dementia). Indeed, it has been estimated that approximately 40% of patients with PD will eventually develop dementia. This entry reviews the diagnostic criteria, neuropathology, and impairments associated with PDD.

Diagnostic Criteria

The vast majority of patients experience parkinsonian symptoms prior to the onset of memory, cognitive, and behavioral dysfunction. Parkinsonian symptoms may include bradykinesia, tremor, shuffling gait, masked face, and other motor signs of motor dysfunction. PDD shares many common features with other subcortical neurodegenerative diseases, such as Lewy body dementia (characterized by the presence of parkinsonsian features, e.g., problems with attention, fluctuations ...

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