Major or Mild Frontotemporal Neurocognitive Disorder

Major or mild frontotemporal neurocognitive disorders mediated by frontotemporal lobar degeneration (FTLD) represent a set of progressive neurodegenerative disorders that are an important cause of cognitive decline in middle-aged and older people. FTLD represents half of primary dementias in individuals aged 45 to 65 years and approximately 5% to 10% of clinically diagnosed dementias across all age-groups. It is distributed equally among men and women. The early stages of the disease are characterized by multiple distinct clinical presentations and pathological origins that are frequently referred to as variants, and include behavioral variant frontotemporal dementia (bvFTD), semantic variant primary progressive aphasia (svPPA), logopenic variant primary progressive aphasia (lvPPA), and nonfluent/agrammatic primary progressive aphasia (naPPA). It should be noted that the primary progressive aphasias (PPAs) can be ...