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Genetic Research

Two strategies are typically used in genetic research focusing on mental health outcomes: (1) behavioral genetics and (2) molecular genetics. The first section of this entry provides an overview of the strategies used in behavioral genetic designs, including twin, adoption, and extended family designs, and summarizes findings relevant to mental health disorders. The second section describes several molecular genetic methods: (a) linkage associations, (b) candidate genes, (c) genome-wide association studies (GWAS), (d) genome-wide complex trait analysis (GCTA), and (e) polygenetic risk scores.

Behavioral and molecular genetics are two strategies for incorporating genetic influences on mental health disorders. Behavioral genetics contribute to the clinical etiology of mental health outcomes by incorporating both genetic and environmental influences to help clarify the developmental mechanisms of mental health disorders. Molecular ...

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