The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), Cultural Formulation Interview (CFI) comprises three sets of semistructured interviews that standardize a clinician’s cultural assessment of a patient and his or her close associates. Clinical research suggests that cultural questions help patients and clinicians overcome communication barriers, clarify the presenting problem and diagnosis, enhance rapport, and improve treatment participation and patient satisfaction. The three parts of the CFI are (1) a core 16-item questionnaire, (2) an informant version of the core CFI to obtain information from a significant person within the person’s social network, and (3) 12 supplementary modules that expand on these basic assessments as needed based on cultural topic or patient population (i.e., children and adolescents, older adults, immigrants and refugees). ...