Combination therapy (CT) refers to the utilization of both psychotherapy and pharmacotherapy in the treatment of mental health disorders. Modern psychiatric practice often favors the notion that more than one form of treatment is necessary to optimize a desired outcome. A combined approach may be utilized at the onset of treatment or after a period of monotherapy. This entry discusses evidence for CT in major mental health disorders and the considerations to be made when using CT in clinical practice.

Evidence for the Effectiveness of CT

Empirical studies of CT have evolved over the decades, starting with competitive trials of medication versus psychotherapy, progressing to studies comparing combined treatments against monotherapies, and most recently examining the augmentative effects of the two on each other in the ...

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