Tolerance occurs when the body adapts to drug usage, reducing the expected or desired effects. This means an increase in dosage is needed to produce the same effects. Tolerance depends on a number of things, most importantly dosage, the type of drug, and how often the drug is used. Drug tolerance can involve both psychological and physiological factors. Tachyphylaxis is a medical term used to describe a rapid onset of drug tolerance. Tachyphylaxis can occur so quickly it may only take a few separate uses of the drug within a few hours before the user has built a tolerance. It is important to note that although a higher dosage of a drug may be needed to achieve the desired effects, the amount needed for a ...

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