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Naltrexone

Naltrexone is a medication that has been found to be efficacious in the treatment of opioid (e.g., heroin, morphine) and alcohol dependence. In 50-milligram (mg) pill form (the dose approved by the U.S. Food and Drug Administration [FDA]), naltrexone goes by the trade name Re Via. In its long-acting injectable form, naltrexone goes by the trade name Vivitrol. Oral naltrexone was approved by the FDA for the treatment of opioid dependence in 1984. In 1994, oral naltrexone was approved by the FDA for the treatment of alcohol dependence, and the injectable form was approved in 2006.

Naltrexone acts as an opioid antagonist, meaning that it binds to opioid receptor sites in the brain and blocks the activity of endogenous opioids such as beta-endorphin, which has a ...

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