Dynamic Treatment Regimens

A dynamic treatment regimen (DTR) is a sequence of individually tailored decision rules that specify whether, how, and when to alter the intensity, type, or delivery of treatment at critical decision points in the medical care process. DTRs operationalize sequential decision making with the aim of improving clinical practice. Ideally, DTRs realize this goal by flexibly tailoring treatments to patients when they need it most, thereby improving the efficacy and effectiveness of treatment and reducing inappropriate variance in treatment delivery. DTRs can be used to develop clinical guidelines, including clinical decision support systems. All the following are types of DTRs: (a) structured treatment interruptions in the HIV/AIDS literature; (b) clinical strategies, treatment strategies, or treatment algorithms in the psychiatric disorders literature; (c) adaptive therapy ...

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