Coagulation is defined as the processes through which the body forms blood clots. Coagulation disorders are those that deal with the body's inability to normally form a blood clot. Disorders of clotting may lead to increased risk of clotting, called thrombosis, or increased risk of bleeding, called hemorrhage.


Disorders of bleeding have been described as far back as the year 2 CE. The word hemophilia was first used in 1828 to describe a bleeding disorder. Fibrin was first described as the substance of a thrombus during this time, followed by the description and isolation of fibrinogen, its soluble precursor. Platelets were first identified in 1865 and their function described in 1882. In the 1920s, von Willebrand disease was first described by Erik von Willebrand. Before the ...

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