The overall objective of this entry is to discuss the significance of personal meaning to the lives of individuals across the life span. The major focus, however, is on establishing the significance of older adults' search for personal meaning and how the attainment of personal meaning may be linked to life satisfactions, social relationships, psychological well-being, and physical health. The discourse will briefly touch on varying definitions of personal meaning emerging from various perspectives (e.g., religious, biological-evolutionary, and existential-humanistic) on the significance of personal meaning.