Glucose intolerance, in the form of type 2 diabetes mellitus (T2DM) or prediabetes, a precursor to the development of T2DM, is a major public health problem. T2DM is an economically costly disease and a major contributor to morbidity and mortality. T2DM can lead to renal dysfunction, peripheral and autonomic neuropathy, vision problems, and cardiovascular disease. In the United States alone, from 2005 to 2050, the prevalence of diagnosed diabetes is expected to more than double from 5.6% to 12.0%. In 2005 to 2006, the prevalence of prediabetes and diabetes combined was estimated to be 42.3% for Americans 20 years or older. The total prevalence of diabetes (diagnosed and undiagnosed) was estimated to be 12.9%, approximately 40% of which was undiagnosed. Worldwide, the number of ...

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