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Yagé is a hallucinogenic drink consumed in indigenous religious rituals in South America. Ayahuasca, as it is known in the native Quechua language, is an Amazonian plant combination that is made by cooking the stem of Banisteriopsis caapi, a vine of the family Malpighiaceae, with the leaves of Psychotria viridis, of the Rubiaceae. In areas of Colombia and Ecuador, the admixture plant is Diplopterys cabrerana, also of the Malpighiaceae, where it is known under the name yagé (also written yajé). B. caapi contains the alkaloids harmine and tetrahydroharmine, with traces of harmaline, while both P. viridis and D. cabrerana contain the powerful visionary alkaloid dimethyltryptamine (DMT). DMT is not orally active, being readily inactivated in the gut and liver by the enzyme monoamine oxidase (MAO). ...

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