During the menopausal transition, there is a natural diminution of the sex hormones estrogen and progesterone. Hormone replacement therapy (HRT), or hormone therapy (HT), is a medical treatment for symptoms related to the menopause and the menopausal transition. Clinically, HT has also been administered to protect against disorders such as osteoporosis and atherosclerotic cardiovascular disease (CVD). However, recent studies have cast doubt on the protective effect of HT and have identified risks involved with its use.

Menopause and HT

Menopause is the permanent cessation of menstruation due to the loss of ovarian follicular function. The perimenopause refers to the time period immediately preceding menopause when fertility wanes and menstrual cycle irregularity increases. This period continues until 12 months after cessation of menses, at which time the woman ...

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