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Chapter 2: Basic Pharmacokinetics of Substance Misuse
Pharmacokinetics has been variously been defined as the study of the relationship between administered doses of a drug and the observed blood (plasma or serum) or tissue concentrations. It is a branch of pharmacology that explores what the body does to a drug and hence concerns itself with the quantitation of drug absorption, distribution, metabolism and excretion (ADME), and more recently liberation (LADME).
Despite the huge size of the pharmaceutical industry and the vast array of psychoactive substances available today for use, the mode of action of drugs in the body can be understood by reference to basic pharmacokinetic principles, assuming a linear relationship between blood and tissue (brain) exposure. Understanding the pharmacokinetic principles of ...