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Chapter 13: Synthetic Cannabinoids: The Pharmacokinetics and Pharmacodynamics of Spice and Other Synthetic Cannabinoids
Synthetic cannabinoids (SC) have emerged over this past decade as drugs of abuse globally. While these products are marketed under different suggestive names, e.g., Spice, K2, Black Mamba, etc., for simplicity, we will refer to all products containing SCs as ‘Spice’ herein. Spice typically contains SCs that are sprayed onto an herbal substrate. Unlike delta-9-tetrahydrocannabinol (THC), the principal psychoactive constituent of herbal cannabis which is a weak partial agonist of brain cannabinoid receptors (CBRs), SCs are potent full CBR agonists (Weissman, Milne et al. 1982; Castaneto, Gorelick et al. 2014).
Spice products are marketed under the guise of potpourri, ...