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Kim P. C. Kuypers, Eef Theunissen & Jan Ramaekers

In: The SAGE Handbook of Drug & Alcohol Studies Volume 2

Chapter 8: Amphetamine & Methamphetamine: Pharmacokinetics and Pharmacodynamics

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Amphetamine & Methamphetamine: Pharmacokinetics and Pharmacodynamics
Amphetamine & Methamphetamine: Pharmacokinetics and Pharmacodynamics
Kim P. C. KuypersEef TheunissenJan Ramaekers
Introduction

The term amphetamines refers to a class of synthetic substances acting as stimulants of the central nervous system (CNS), including amphetamine (R,S-1-phenyl-2-propanamine), that can take different chemical forms such as l-amphetamine, d-amphetamine (Dexedrine), d,l-amphetamine (Benzedrine) and a mixture of amphetamine stereoisomer salts and inactive ingredients (Adderall), and other chemicals which share structural similarities e.g. methamphetamine (R,S-N-methyl-1-phenyl-2-propanamine; Desoxyn) (Kraemer and Maurer, 2002; Couper and Logan, 2004; Meyer and Quenzer, 2005; Fleckenstein et al., 2007). Therapeutically, amphetamine is used to treat attention deficit hyperactivity disorder (ADHD), narcolepsy and extreme obesity. Methamphetamine is rarely used in the treatment of ADHD and obesity (Couper and Logan, 2004; Fleckenstein et al., 2007).

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