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Fujian Song, Alison Eastwood, Simon Gilbody, Lelia Duley & Alex Sutton

In: The Advanced Handbook of Methods in Evidence Based Healthcare

Chapter 21: Publication and Related Biases

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Publication and Related Biases
Publication and related biases

The available evidence demonstrates that research with significant results or favourable results is more likely to be published than that with non-significant or unfavourable results, although the extent and direction of such selective publication is uncertain, and may vary greatly depending on the circumstances. Investigators, journal editors, peer-reviewers and research sponsors may all be responsible for the existence of publication bias. Methods available to detect or adjust for publication bias in systematic reviews are by nature indirect and exploratory. Results from a sample of systematic reviews revealed that potential publication bias has been ignored in many published systematic reviews. It is concluded that all funded or approved studies should be prospectively registered. Further research about publication bias should ...

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