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By: Decision Resources Inc

In: The SAGE Handbook of Healthcare

Chapter 39: Emerging Diagnostic Markers in Alzheimer's Disease

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Emerging Diagnostic Markers in Alzheimer's Disease
Emerging diagnostic markers in alzheimer's disease
Introduction

Alzheimer's disease (AD) is a neuro-degenerative disease. During its course, neurons die progressively because of the accumulation of neurotoxic proteins that form Aβ-amyloid plaques and neurofibrillary tangles (NFTs). Unlike other cells, neurons do not self-renew; consequently, the number of functioning brain cells in an AD patient's brain decreases as the disease progresses. The decrease in the number of brain cells accounts for the severity of AD symptoms at moderate and late stages of the disease. The accumulation of Aβ-amyloid plaques and NFTs begins years before the disease symptoms become apparent. Several drugs that prevent or slow the accumulation of Aβ-amyloid plaques are in development for treatment of AD, and we expect two of these ...

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