• Summary
  • Contents
  • Subject index

With escalating healthcare costs, changes to the regulatory control on pharmaceutical industries and the inevitable adjustments made in policies and investment in healthcare there is enormous interest in the commercial as well as the scientific aspects of today's healthcare industry.

The SAGE Handbook of Healthcare provides an authoritative analysis of the current (and anticipated) developments in the global healthcare industries. Providing a unique perspective that interfaces between the science and business aspects, it combines information on the latest scientific developments with applied, commercial business data from the global marketplace.

The Handbook focuses on the aspects of paramount importance in the healthcare sector: Pharmacoeconomics; Pharmacogenomics; Therapeutics; Diagnostics

Areas covered include: The role of nanotechnology, genomics and cell therapy in medicine; Diagnostics; Biomarkers and technological advances; Case studies in oncology ...

Renin Inhibitors: A Novel Approach to Hypertension
Renin inhibitors: A novel approach to hypertension
Introduction

Hypertension, or high blood pressure (BP), is a significant health concern worldwide. It is a major risk factor for cardiovascular disease (CVD), and poorly controlled hypertension, especially if prolonged, can damage target organs, such as the heart, kidneys, the retina of the eye, and the brain. Over time, this target organ damage can result in heart failure, end-stage kidney disease, retinopathy, stroke, and vascular dementia.

Essential hypertension (hypertension with no known cause) accounts for approximately 90% of hypertension and is usually treated with oral antihypertensive drugs. In 2005, the market for these agents exceeded $25 billion in the seven major pharmaceutical markets under study (United States, France, Germany, Italy, Spain, United Kingdom, and ...

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