• Summary
  • Contents
  • Subject index

With escalating healthcare costs, changes to the regulatory control on pharmaceutical industries and the inevitable adjustments made in policies and investment in healthcare there is enormous interest in the commercial as well as the scientific aspects of today's healthcare industry.

The SAGE Handbook of Healthcare provides an authoritative analysis of the current (and anticipated) developments in the global healthcare industries. Providing a unique perspective that interfaces between the science and business aspects, it combines information on the latest scientific developments with applied, commercial business data from the global marketplace.

The Handbook focuses on the aspects of paramount importance in the healthcare sector: Pharmacoeconomics; Pharmacogenomics; Therapeutics; Diagnostics

Areas covered include: The role of nanotechnology, genomics and cell therapy in medicine; Diagnostics; Biomarkers and technological advances; Case studies in oncology ...

Novel Strategies in Oncology Clinical Trials: The Use of Biological and Imaging Biomarkers
Novel strategies in oncology clinical trials: The use of biological and imaging biomarkers
Improving Cancer Therapies: Going beyond Survival

The gold standard for evaluating an oncology drug candidate's effectiveness is survival. However, the emergence of biotherapeutics for use in oncology has shifted attention to intermediate indicators of progress in patient-treatment evaluations. By evaluating immunological responses to biotherapeutics, insight may be gained into potential therapeutic improvements to optimize dosage, delivery, and combinations with other therapeutics. Evaluation of the immune response requires quantifying the biological changes, or creating “biomarkers,” that can be related to clinical outcomes. As we discuss, both biological biomarkers and imaging biomarkers are emerging to fill this role.

The development and application of these ...

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