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Chapter 3: Atypical Sexual Differentiation
Under ordinary circumstances each step in the sexual differentiation process is contingent upon and consistent with the former. In intersex conditions, there are incongruities between one or more steps in sexual differentiation (chromosomal, gonadal, hormonal, or genital). At a certain point the development deviates from the normal male or female route (Table 3.1). Prevalence figures for intersex conditions are not known. Depending on the [Page 24]definition of intersex, population estimates range from 0.1 to 2% (Blackless et al., 2000).
At fertilization, when chromosomal sex is established, an unusual chromosome configuration may develop. Examples of such configurations are karyotypes of 47,XXY (Klinefelter Syndrome, KS) or 45,XO (Turner ...