Female sexual interest/arousal disorder (FSIAD) is a clinical diagnosis characterized by significant absence of or decrease in sexual functioning and thoughts and fantasies about sex, causing substantial clinical distress. Women experiencing this problem commonly report symptoms such as lack of a sex drive and difficulty becoming lubricated or aroused during sexual activity. Categorized as a sexual dysfunction in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), FSIAD can be highly disruptive and can occur at any stage of the sexual response cycle, including the desire, arousal, orgasm, and resolution stages. This entry provides an overview of symptoms, causes, and treatments associated with FSIAD.