• Entry
  • Reader's guide
  • Entries A-Z
  • Subject index

Wilson’s Disease

Copper is an essential metal that is an important cofactor for cellular function, yet free copper is extremely toxic and can produce irreversible cellular damage. Wilson’s disease is a genetic disorder in which copper accumulates in the tissues and manifests as neurological and/or psychiatric symptoms often in conjunction with liver disease. Wilson’s disease was first described in 1912 by Kinnear Wilson as hepato-lenticular degeneration, a familial, lethal neurological disease accompanied by chronic liver disease leading to cirrhosis. It is a condition seen worldwide and is an important diagnosis for clinicians to consider in patients who present with neuropsychiatric dysfunction and liver disease. It is a common yet treatable cause of liver failure in young people, and as such an early diagnosis and initiation of ...

    • Loading...
    locked icon

    Sign in to access this content

    Get a 30 day FREE TRIAL

    • Watch videos from a variety of sources bringing classroom topics to life
    • Read modern, diverse business cases
    • Explore hundreds of books and reference titles