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Latin square design is a type of experimental design that can be used to control sources of extraneous variation or nuisance factors. Latin squares design is an extension of the randomized complete block design and is employed when a researcher has two sources of extraneous variation in a research study that he or she wishes to control or eliminate. This entry addresses how to set up a study using Latin square design, the advantages and disadvantages of this design approach, and the analysis of data when using Latin square design.

Let us begin with an example to illustrate why one might use a Latin square design in an experimental study. Perhaps you want to test the influence of four different protocols for producing a product ...

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