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The Belmont Report is a fundamental resource for researchers, based on key ethical principles, to provide guidance for the protection of human subjects participating in clinical research.

Addressing a Need

Public attention began to focus on the ethics of research involving human subjects after the end of World War II, as details surrounding the atrocities of the medical experiments performed on concentration camp inmates by the Nazis without informed consent became known throughout the world. Issues of research with human subjects also arose in the United States, with the Tuskeegee syphilis trials (1932–1973), in which hundreds of men participated without informed consent and those with syphilis were not given treatment that could have cured their disease, and the Willowbrook hepatitis trials (1956–1971), in which several developmentally delayed ...

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