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The term gender dysphoria (GD) denotes distress or discomfort with one’s biologic sex or assigned gender. GD also refers to both an overarching diagnostic category and a group of specific diagnoses in the American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). A diagnosis of GD is applicable to persons who experience significant distress or functional impairment as a result of profound discomfort with their biologic sex or assigned gender. The most widely known, extensively studied, and extreme form of GD is transsexualism, applicable to persons who experience an intense desire to undergo sex reassignment: that is, to live as members of the other sex and undergo hormonal and surgical treatment in order to make their bodies resemble those of ...

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