Demographic trends that emerged in the 20th century have resulted in a large increase in the numbers of individuals in the U.S. population from racial and ethnic minority groups. These demographic trends are projected to continue such that by the year 2100 non-Hispanic Whites are expected to comprise only 40% of the U.S. general population. As the numbers of individuals from traditional racial and ethnic minorities increases, the need for culturally tailored prevention and intervention for substance abuse issues among individuals from racial and ethnic minority populations increases. This entry presents information on the prevalence of substance use among racial and ethnic minority populations, discusses issues in the prevention of substance abuse among these groups, and presents an introduction to the public health model for ...