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Nuclear Reprogramming

  • By: Brenda Ogle & Ho—Pi Lin
  • In: Encyclopedia of Stem Cell Research
  • Edited by: Clive N. Svendsen & Allison D. Ebert
  • Subject:Ethics in Health Care (general), Medical Research

DIFFERENTIATED OR MATURE cells of the body were once thought to be capable of giving rise to cells of the same type only. However, several distinct lines of research have shown that nuclei of mature cells can be “reprogrammed” to give rise to pluripotent cells—cells capable of generating the many different cells types of the body. Generating patient—specific pluripotent cells could greatly improve efforts to repair and replace organs and tissues by obviating the need for cell donors and circumventing the possibility of donor cell rejection.

Nuclear Transfer

Somatic cell nuclear transfer is arguably the most well known and extensively studied approach to inducing nuclear reprogramming of mature/terminally differentiated cells. This approach involves removing the nucleus of an oocyte and replacing it with the nucleus of ...

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