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As in other branches of science, the time-honored method of research in the realm of medicine is one factor at a time. This practice of minimizing or eliminating changes in all factors of interest and then, one by one, changing the levels of each factor and recording the responses to those changes has been and continues to be used for the simple reason that it works and because most researchers do not realize that better methods exist. From the standpoint of efficiency with respect to time, money, effort, and quality of results, one-factor-at-a-time research is a failure.

A factor is any variable whose changes might result in responses of interest to an investigator. Factors include, but are not limited to, things such as dosage levels of ...

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