• Entry
  • Reader's guide
  • Entries A-Z
  • Subject index

Exercise, Heavy Exertion, and Immune Dysfunction

Physical activity influences immune function and risk of certain types of infection such as upper respiratory tract infections (URTI). In contrast to moderate physical activity, prolonged and intensive exertion lasting 90 minutes or longer by endurance athletes causes numerous changes in immunity in multiple body compartments and an increased risk of URTI. Each acute bout of heavy exertion leads to physiological stress and clinically significant changes in immunity and the capacity to detect and kill invading bacteria and viruses. Stressful levels of exercise affect both the innate and the adaptive immune system.

Innate Immune System

The innate immune system consists of anatomical and physiological barriers (skin, mucous membranes, body temperature, low pH, and special chemical mediators such as complement and interferon), specialized cells (natural killer [NK] cells ...

    • Loading...
    locked icon

    Sign in to access this content

    Get a 30 day FREE TRIAL

    • Watch videos from a variety of sources bringing classroom topics to life
    • Read modern, diverse business cases
    • Explore hundreds of books and reference titles